Figure 5. Cysteine patterns and disulfide bond connectivity predictions for Shisa and Shisa-like proteins.
(a) The six conserved cysteines in Shisa-like proteins are labeled from 1 to 6. Cysteine pairs with inferred disulfide bond connectivity are connected by dashed lines. Mutations in the cysteine positions are marked by ‘X’s. (b) Disulfide bond connections are shown for two protein domains with known structures and containing the cysteine pattern ‘C*C*CC*CC’.