Skip to main content
. 2012 Feb 17;8:99–113. doi: 10.2147/VHRM.S25665

Figure 4.

Figure 4

Bone marrow-derived stem cell mobilization. Bone marrow stem cells may be mobilized by reducing the ligand SDF-1 and increasing the stem cell receptor CXCR4 to create a chemotatic gradient with the peripheral blood. G-CSF treatment increases MMP-9 to regulate changes in SDF-1/CXCR4 pathway, which is dependent on plasmin activation of MMP-9.

Reprinted with permission, Cleveland Clinic Center for Medical Art & Photography © 2011–2012. All Rights Reserved.

Abbreviations: CXCR4, C-X-C receptor 4; G-CSF, granulocyte colony-stimulating factor; MMP-9, matrix metalloproteinase-9; SDF-1, stromal-derived factor-1.