Table 1.
Ongoing clinical trials of stem-cell therapy for heart diseases
| Condition | Stem cells | Phase | Acronym | ClinicalTrials.gov NCTID |
|---|---|---|---|---|
| Congestive heart failure | Skeletal myoblasts | II/III | MARVEL | NCT00526253 |
| Old MI | Skeletal myoblasts | II | PERCUTANEO | NCT00908622 |
| Angina, coronary disease | Bone marrow | II | NCT01214499 | |
| Ischemic heart disease | Bone marrow | II | NCT00690209 | |
| CAD, AMI | Bone marrow | I/II | REPAIR-ACS | NCT00711542 |
| MI, ischemia | Bone marrow | I/II | NCT01267331 | |
| AMI | Bone marrow | II/III | REGEN-AMI | NCT00765453 |
| CAD | Bone marrow | II/III | NCT00130377 | |
| Chronic ischemic heart failure | Bone marrow | II/III | REGEN-IHD | NCT00747708 |
| MI | Bone marrow/AC 133 | III | NCT01167751 | |
| Congestive heart failure | Bone marrow | I/II | NCT01061580 | |
| Non-ischemic dilated cardiomyopathy | Bone marrow | I/II | POSEIDON-DCM | NCT01392625 |
| Dilated cardiomyopathy | Bone marrow | II | NOGA-DCM | NCT01350310 |
| Cardiomyopathy | Bone marrow | II | REGENERATE-DCM | NCT01302171 |
| Ischemic heart failure | Bone marrow/PBC | III | ESCAPE | NCT00841958 |
| Left ventricular dysfunction | Bone marrow | II | TIME | NCT00684021 |
| Left ventricular dysfunction | MSC, bone marrow | I/II | TAC-HFT | NCT00768066 |
| Ischemia, left ventricular dysfunction | MSC | I/II | MESAMI | NCT01076920 |
| MI | Mesenchymal precursors | I/II | NCT00555828 | |
| AMI, heart failure | MSC | III | ESTIMATION | NCT01394432 |
| Chronic ischemic heart disease | MSC | II | MyStromalCell | NCT01449032 |
| Congestive heart failure | MSC | I/II | NCT00644410 | |
| Dilated cardiomyopathy | CD34+ | II | NCT00629018 | |
| AMI | CD133+ | SELECT-AMI | NCT00529932 | |
| MI | CD133+ | II/III | NCT01187654 | |
| MI, CAD | CD133+ | I/II | PERFECT | NCT00950274 |
| CAD | CD133+ | III | NCT01049867 | |
| MI, heart failure | CD133+ | II | IMPACT-CABG | NCT01033617 |
| AMI | Adipose tissue-derived | II/III | ADVANCE | NCT01216995 |
| Heart failure | Cardiac progenitor | I | TICAP | NCT01273857 |
| Congestive heart failure | Cardiac | I | ALCADIA | NCT00981006 |
| MI | Cardiosphere | I | CADUCEUS | NCT00893360 |
| CAD, congestive heart failure | Cardiac | I | SCIPIO | NCT00474461 |
Source: ClinicalTrials.gov Website.7
Abbreviations: AMI, acute myocardial infarction; CAD, coronary artery disease; MI, myocardial infarction; MSC, mesenchymal stem cell; PBC, peripheral-blood cell.