Table 1.
Associations between DACH2 expression and clinicopathological parameters in all patients and patients with serous carcinoma.
| All | Serous carcinoma | |
|---|---|---|
| Factor | DACH2 | DACH2 |
| Age | ||
| R | 0.044 | 0.078 |
| p | 0.603 | 0.483 |
| n | 143 | 84 |
| Differentiation grade | ||
| R | -0,031 | -0.189 |
| p | 0.716 | 0.086 |
| n | 143 | 84 |
| Clinical stage | ||
| R | 0.025 | 0.078 |
| p | 0.779 | 0.494 |
| n | 131 | 80 |
| Ki67 | ||
| R | 0.208 | 0.086 |
| p | 0.013* | 0.435 |
| n | 141 | 84 |
| AR | ||
| R | 0.028 | -0.045 |
| p | 0.738 | 0.683 |
| n | 143 | 84 |
| ER | ||
| R | 0.122 | -0.067 |
| p | 0.151 | 0.554 |
| n | 139 | 81 |
| PR | ||
| R | 0.130 | 0.085 |
| p | 0.126 | 0.437 |
| n | 141 | 85 |
| RBM3 | ||
| R | -0,072 | -0.167 |
| p | 0.393 | 0.129 |
| n | 141 | 84 |
| Chek1 | ||
| R | 0.194 | 0.139 |
| p | 0.024* | 0.225 |
| n | 134 | 78 |
| Chek2 | ||
| R | 0.182 | 0.155 |
| p | 0.032* | 0.164 |
| n | 139 | 78 |
| MCM3 | ||
| R | 0.252 | 0.104 |
| p | 0.003** | 0.360 |
| n | 134 | 79 |
R = Spearman's correlation coefficient, p = p-value, n = number of cases available for analysis. ER = estrogen receptor, PR = progesterone receptor, AR = Androgen receptor. *significance at 5% level, ** significance at 1% level. The analysis are based on multipliers of staining intensity and fraction (nuclear score) for DACH2, RBM3, Chek1, Chek2 and MCM3 and categories of nuclear fraction for Ki67, AR, ER, and PR.