Table 2.
Relative risks of death from ovarian cancer and overall death according to DACH2 expression in all patients and patients with serous carcinoma.
| Ovarian cancer specific survival | Overall survival | |||||
|---|---|---|---|---|---|---|
| HR(95%CI) | p-value | n(events) | HR(95%CI) | p-value | n(events) | |
| All | Univariable | Univariable | ||||
| DACH2 low | 1,00 | 0.048 | 60 | 1,00 | 0.022 | 60 |
| DACH2 high | 1.54(1.00-2.35) | 83 | 1.63(1.07-2.47) | 83 | ||
| Multivariable | Multivariable | |||||
| DACH2 low | 1,00 | 0.182 | 55 | 1,00 | 0.088 | 55 |
| DACH2 high | 1.36(0.87-2.12) | 76 | 1.57(0.95-2.28) | 76 | ||
| Serous carcinoma | Univariable | Univariable | ||||
| DACH2 low | 1,00 | 0.010 | 28 | 1,00 | 0.005 | 28 |
| DACH2 high | 2.21(1.21-4.04) | 56 | 2.34(1.23-4.26) | 56 | ||
| Multivariable | Multivariable | |||||
| DACH2 low | 1,00 | 0.035 | 25 | 1,00 | 0.022 | 25 |
| DACH2 high | 2.01(1.05-3.85) | 51 | 2.13(1.12-4.08) | 51 | ||
Cox uni- and multivariable analysis of relative risks of death from ovarian cancer and overall death according to DACH2 expression in all patients and patients with serous carcinoma. HR = Hazard ratio. The categories of staining were determined according to the nuclear score (NS), e.g. a multiplier of fraction and intensity, whereby low expression = NS < = 3 and high expression = NS > 3. Multivariate analysis included adjustment for differentiation grade (low-intermediate vs high) and clinical stage (1-2 vs 3 and 4).