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Zonated glutamine cycling in the liver. (A) β-catenin exerts either negative or positive control on glutaminase and glutamine synthetase, respectively. Periportal glutamine consumption is catalyzed by glutaminase. Perivenous glutamine synthesis is catalyzed by glutamine synthetase. (B) Daily glutamine consumption is higher in μFB cultures than in PD cultures. Data are expressed as mean ± SD (N = 6).
