Table 2.
Summary of DAVID Gene Ontology analysis of genes near LRH-1 binding regions
| Category | Term | GO Term | Count | % | P value | Benjamini | FDR |
|---|---|---|---|---|---|---|---|
| GOTERM_BP | GO:0044255 | Cellular lipid metabolic process | 25 | 9.73 | 1.07E-06 | 0.00552 | 0.002 |
| GOTERM_BP | GO:0006629 | Lipid metabolic process | 26 | 10.12 | 3.88E-06 | 0.01003 | 0.0074 |
| GOTERM_BP | GO:0008152 | metabolic process | 141 | 54.86 | 1.82E-05 | 0.031 | 0.0348 |
| GOTERM_BP | GO:0008202 | Steroid metabolic process | 10 | 3.89 | 2.95E-04 | 0.31791 | 0.5618 |
| GOTERM_BP | GO:0044237 | Cellular metabolic process | 125 | 48.64 | 3.00E-04 | 0.26791 | 0.5722 |
| GOTERM_BP | GO:0008203 | Cholesterol Metabolic Processes | 7 | 2.72 | 3.97E-04 | 0.29075 | 0.7557 |
| GOTERM_BP | GO:0016125 | Sterol metabolic process | 7 | 2.72 | 6.63E-04 | 0.3885 | 1.259 |
| GOTERM_BP | GO:0044238 | Primary metabolic process | 123 | 47.86 | 8.15E-04 | 0.41083 | 1.5454 |
| GOTERM_BP | GO:0008610 | Lipid biosynthetic process | 12 | 4.67 | 8.48E-04 | 0.38705 | 1.608 |
| GOTERM_BP | GO:0009058 | Biosynthetic process | 33 | 12.84 | 0.001103 | 0.43623 | 2.0869 |
| GOTERM_BP | GO:0044248 | Cellular catabolic process | 16 | 6.23 | 0.002877 | 0.74332 | 5.356 |
| GOTERM_BP | GO:0032787 | Monocarboxylic acid metabolic process | 10 | 3.89 | 0.004361 | 0.84904 | 8.0104 |
| GOTERM_BP | GO:0006066 | Alcohol metabolic process | 11 | 4.28 | 0.005747 | 0.89995 | 10.428 |
| GOTERM_BP | GO:0006631 | Fatty acid metabolic process | 8 | 3.11 | 0.008909 | 0.86381 | 15.716 |
| GOTERM_BP | GO:0019752 | Carboxylic acid metabolic process | 15 | 5.84 | 0.010269 | 0.97193 | 17.899 |
| GOTERM_BP | GO:0006082 | Organic acid metabolic process | 15 | 5.84 | 0.010587 | 0.96837 | 18.4 |
367 genes close to LRH-1 peaks that overlap with FXR peaks were used to group into enriched functionally important categories using the PANTHER "Biological Process" term