Table 1.
Dose study of oral challenge with edema toxin
| Oral dosage | n | Median | Minimum/maximum | Relative median weighta (%) | P value |
|---|---|---|---|---|---|
| No toxin | 12 | 9.49 | 7.06/10.43 | ---- | ----- |
| 10 μg ET | 5 | 9.51 | 7.12/10.49 | 0.21 | NS |
| 25 μg ET | 6 | 10.24 | 8.27/10.94 | 7.90 | NS |
| 50 μg ET | 6 | 10.71 | 10.39/11.44 | 12.86 | < 0.05b |
| 100 μg ET | 5 | 10.69 | 10.46/11.65 | 11.87 | < 0.05b |
Median (minimum and maximum) relative intestinal weight in percent total body weight upon challenge with increasing doses of edema toxin. a The difference in median of relative intestinal weight between experimental group and mice receiving no toxin in percent. b Represents a statistically significant difference of P< 0.05 compared with mice receiving no toxin using the Mann-Whitney U-test.