Table 2.
Mouse model of oral challenge by edema toxin
| Oral dosage | n | Median | Minimum/maximum | Relative median weighta (%) | P value compared to KKA317 only | P value compared to ET only |
|---|---|---|---|---|---|---|
| ET only | 4 | 10.67 | 10.48/11.53 | 12.55 | < 0.05b | ---- |
| KKA317 only (negative control) | 5 | 9.48 | 7.13/10.51 | ---- | ----- | < 0.05c |
| KKA317 + ET | 8 | 9.53 | 7.25/10.89 | 0.53 | NS | < 0.05c |
| L. paracasei pAF400 + ET | 3 | 10.99 | 9.99/11.05 | 15.93 | < 0.05b | NS |
Median (minimum and maximum) relative intestinal weight in percent total body weight upon challenge with either ET, recombinant Lactobacillus or both. a The difference in median of relative intestinal weight between group and negative control KKA317 in percent. b Represents a statistically significant difference of P< 0.05 compared with mice only receiving KKA317 using the Mann-Whitney U-test. c Represents a statistically significance of P< 0.05 compared with mice receiving only ET toxin using the Mann-Whitney U-test.