Table 3.
Enrichment analysis of high confidence LXR target genes
| Term | Count | % | P | FE | FDR |
|---|---|---|---|---|---|
| translation | 16 | 6.56 | 9.14E-05 | 3.34 | 0.15 |
| lipid biosynthetic process | 15 | 6.15 | 2.48E-04 | 3.21 | 0.41 |
| cellular response to stress | 20 | 8.20 | 5.40E-04 | 2.44 | 0.89 |
| RNA splicing | 13 | 5.33 | 8.58E-04 | 3.16 | 1.41 |
| response to virus | 8 | 3.28 | 1.00E-03 | 5.07 | 1.64 |
| positive regulation of gene-specific transcription | 7 | 2.87 | 1.59E-03 | 5.55 | 2.60 |
| RNA splicing, via trans-esterification reactions | 9 | 3.69 | 1.68E-03 | 4.06 | 2.75 |
| nuclear mRNA splicing, via spliceosome | 9 | 3.69 | 1.68E-03 | 4.06 | 2.75 |
| RNA splicing, via trans-esterification reactions with bulged adenosine as nucleophile | 9 | 3.69 | 1.68E-03 | 4.06 | 2.75 |
| RNA processing | 18 | 7.38 | 2.41E-03 | 2.27 | 3.90 |
| negative regulation of cholesterol storage | 3 | 1.23 | 2.98E-03 | 34.51 | 4.82 |
The analysis was performed using the DAVID tool [37] for the specific set of LXR target genes with P < 0.001 for differential expression. GO biological process terms with FDR < 5% are shown. Columns indicate the GO-term, its count and percentage in the target gene list, as well as the P-value, FE and FDR for the enrichment.