Table 5.
Summary of genes regulated by IL-3, BCR-ABL, TEL-PDGFRB and TEL-JAK2 at steady-state (1 week).
| Gene Name | IL-3 | BCR-ABL | TEL-PDGFRB | TEL-JAK2 |
|---|---|---|---|---|
| Dok2 | - | Up* | - | - |
| Daf1 | - | Up | Down | - |
| Ndrg1 | - | Up | Down | - |
| Stat1 | - | - | Up | - |
| Gbp1 | - | - | Up | ? |
| Isg20 | - | - | Up | Up |
| Id1 | Up* | Up | Up* | - |
| Mrvi1 | - | Up | Up | - |
| Gp49b | Up | Up* | - | Up |
| Cxcl10 | - | Up | Up | Up |
| Scin | - | Down | Down | Down |
| Col5a1 | Down | Down | Down* | - |
All genes were validated by Q-PCR using RNA samples extracted from 2-5 distinct cell populations. Data represent mean fold-change in gene expression at 1 week compared to the expression at 0 h and SEM. All changes in gene expression were associated with p-value < 0.05 as determined by a student t-test unless indicated by asterisk, which denotes p-value < 0.1. Dotted line (-) indicates no significant change
In addition, Cxcl10 was confirmed to be induced by all three fusions even though it was initially identified as a TEL-PDGFRB-regulated gene (Tables 2 & 5).