Figure 4. Heatmap and CGI probe loci distributions of the five categories of methylation pattern maintenance.

The normalized methylation signals for loci in five different methylation patterns were compared, ranging as vertically Parental replicate dyes and generation 1, 3, 5 cisplatin treated dyes, and horizontally heritable high methylation (1186 CGI loci), heritable low methylation (286 loci), random methylation (582 loci), stochastic hypermethylation (243 loci), and stochastic hypomethylation (247 CGI loci). “parental rep 2” indicates the average of parental dyes of non-swap and swap microarray experiments, while “gene-3 cells” is the average of corresponding generation 3 dyes.