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. Author manuscript; available in PMC: 2013 Mar 15.
Published in final edited form as: Bioorg Med Chem Lett. 2012 Feb 1;22(6):2242–2246. doi: 10.1016/j.bmcl.2012.01.095

Table 1.

Anthrax LF inhibitory data for LFIs bearing α-benzyl substituents on the C2-side chain.

graphic file with name nihms358195u1.jpg
LFI (*) R LF (FRET)
KinM)
9 R Me 0.30
10 S Me 0.49
11 R Et 0.04
12 S Et 0.11
13 R iso-butyl 0.23
14 S iso-butyl 1.30
15 R -CH2Ph 0.60
16 S -CH2Ph 2.00

Values are the average of two experiments; sd < 15%