Table 1.
Distribution of CRF receptors and ligands (mRNA and immunoreactivity) in human and rodent colon and ileum.
| Receptors | |||||||
|---|---|---|---|---|---|---|---|
| COLON | ILEUM | ||||||
| Human | Rodent | Human | Rodent | ||||
| CRF1 | SNP | (33) | Goblet cells | (26,39,40) | ND | Epithelial cells | (50,52) |
| MNP | Crypts (stem cells) | LP | |||||
| LP (mast cell, macrophages) | (33,34,38) | SNP | (41) | SNP | (45,49) | ||
| MNP | MNP | ||||||
| LP (few cells) | (40) | ||||||
| Epithelium (few cells) | |||||||
| CRF2 | Epithelial cells (weak) | (34–36) | Crypts (luminal surface) | (40) | ND | LP cells (weak) | (50,52) |
| SNP | (37) | MNP | (40,45) | ||||
| MNP | Submucosal layer (blood vessels) | SNP | |||||
| SML | |||||||
| VEC | |||||||
| VSMC | |||||||
| LP (und. inflammatory cells) | (34) | ||||||
| LP (mast cells) | (38) | ||||||
| Ligands | |||||||
|---|---|---|---|---|---|---|---|
| COLON | ILEUM | ||||||
| Human | Rodent | Human | Rodent | ||||
| CRF | Mucosa | (43) | Epithelial cells | (10,44) | ND | Epithelial cells (weak) | (50) |
| Enterochromaffin cells | Mucosa | (50,51) | |||||
| Submucosa/muscle layer | Paneth cells | ||||||
| MNP | |||||||
| LP | SNP | (45) | |||||
| MNP | (44–47) | LP | |||||
| SNP | |||||||
| Ucn 1 | Epithelial cells (weak) | (34) | MNP | (46,47) | ND | ND | |
| LP macrophages | SNP | ||||||
| Ucn 2 | ND | Epithelial cells | (48) | ND | Epithelial cells | (48) | |
| MNP | MNP | ||||||
| SNP | SNP | ||||||
| Muscle layer | Muscle layer | ||||||
| Ucn3 | Enterochromaffin cells | (37) | ND | ND | ND | ||
| MNP | |||||||
| SNP | |||||||
| VEC | |||||||
| VSMC | |||||||
| SML | |||||||
| Enteric glial cells | |||||||
SNP: submucosal neuronal plexus, MNP: myenteric neuronal plexus, VEC: vascular endothelial cells, VSMC: vascular smooth muscle cells, SML: smooth muscle layer, LP: lamina propria, ND: non determined.