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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Matrix Biol. 2012 Jan 12;31(3):197–205. doi: 10.1016/j.matbio.2012.01.001

Fig. 5. Aged Eln+/− aortic valves demonstrate increased MMP-2 and MMP-9 expression.

Fig. 5

MMP-2 expression (A–B) was higher in both cusp and annulus tissue compared to MMP-9 expression (C–D). Both MMP-2 and MMP-9 expression was unchanged in the cusp region (p=NS, E) and increased in the annulus region (p<0.01, E) in aged Eln+/− valves (B″, D″), as compared to WT valves (A″, C″). MMP-2 and MMP-9 are stained green; cell nuclei, blue (ToPro3). Cusps (A′ – D′), annulus (A″ – D″). Sections are oriented in the long axis. Scale bars: 60 μm (A–D); 10 μm (all others). Dotted lines isolate valve tissue from aortic and/or myocardial tissue.