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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Matrix Biol. 2012 Jan 12;31(3):197–205. doi: 10.1016/j.matbio.2012.01.001

Fig. 6. Progressive increase in remodeling enzyme activity in Eln+/− aortic valve tissue.

Fig. 6

Gelatin zymography showed modest MMP-2 (arrow, A) and MMP-9 activity in juvenile WT valves, consistent with normal developmental remodeling and growth. In Eln+/− aortic valves, both MMP-2 and MMP-9 activity was significantly increased at juvenile stage (arrowheads, A) before the onset of AVD (p<0.05, B), and increased dramatically at the aged stage after the onset of AVD (red boxes, A) (p<0.0001, B). (* different from WT; # different from 1 mo; ^ different from 4 mo, B).