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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Matrix Biol. 2012 Jan 12;31(3):197–205. doi: 10.1016/j.matbio.2012.01.001

Fig. 7. Regional biomechanical dysfunction in aged Eln+/− mouse aortic valve tissue.

Fig. 7

Young’s modulus, a measure of tissue stiffness, was significantly larger in the aortic valve annulus region, as compared to the cusp region in both Eln+/− and WT valves at all stages (p<0.0001). Young’s modulus decreases significantly in the aged (12 mo) Eln+/− cusp and annulus regions compared to age-matched WT (p<0.005) and younger Eln+/− mice (p<0.0001). (* different from WT; # different from 1 mo; ^ different from 4 mo).