Table 1.
Experimental protocol
| Experimental day | 1 | 2-6 | 7-9 | 10 |
|---|---|---|---|---|
| Treatment | Saline | 2.5mg/kg | Washout | Saline |
| 2.5mg/kg | 2.5mg/kg |
On experimental day 1 (ED1), neuronal recordings were performed after saline injection (baseline) for 30 minutes and continued for 90 minutes following 2.5mg/kg injection of MPD. Rats on ED2-6 were injected once a day in the morning (8 am) with 2.5mg/kg MPD. ED7 through ED9 were washout days (drug abstinence). Neuronal recordings resumed on ED10 after saline (baseline) and 2.5mg/kg MPD. On ED10 rats were treated identical as in ED1.