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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Hepatology. 2012 Mar 1;55(4):1083–1093. doi: 10.1002/hep.24793

Figure 3. Reduced Klf6 and glucokinase expression in DeltaKlf6 mice.

Figure 3

While expression of Klf6, Gck and Gckr mRNA was not significantly suppressed in whole liver tissues in DeltaKlf6 mice compared to wild type littermates (n=7) (n=7) (A), levels were markedly suppressed in primary hepatocytes isolated from DeltaKlf6 mice (n=3) (D). Data are presented as fold change (FC) relative to wt littermates. Known transcriptional activators of Gck were not reduced in the presence of reduced Gck in deltaKlf6 mice (B & E). Western blot of both whole tissues and isolated hepatocytes confirmed decreased Gck protein in association with reduced Klf6. (* denotes p-value<0.05; **p-value<0.005)