Figure 4. Increased Klf6 and glucokinase expression in vitro in Klf6 transfected AML12 cells.
Increased Klf6 and Gck expression were present in the murine hepatoma cell line, AML12 after transfection with a plasmid vector expressing Klf6 (A, C). Known transcriptional activators of Gck remained unchanged. Hnf4a mRNA was downregulated indicating counter-regulatory mechanisms (B). (* = p<0.05).