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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Hepatology. 2012 Mar 1;55(4):1083–1093. doi: 10.1002/hep.24793

Figure 5. KLF6-FL and GCK are reduced with advanced steatosis, while elevated KLF6-SV1 is associated with suppressed GCKR.

Figure 5

Expression of the KLF6 full-length isoform (KLF6-FL) correlated positively with GCK expression (A). In contrast, expression of KLF6-SV1 was associated with a dramatic reduction in expression of GCKR (B). KLF6-FL expression was significantly suppressed with more advanced steatosis (grade 2+3) while KLF6-SV1 was significantly upregulated (C). Both GCK and GCKR were significantly downregulated in patients with advanced steatosis (grade 2+3) (D). (* = p<0.05; ** = p<0.01).