Table 1. KLF6 Genotype and NAFLD related associations in normal individuals.
Table 1A includes variables classed by genotype for the cohort of 1250 individuals, while Table 1B presents subset data for those in which endogenous glucose production (EGP) was measured. Non-parametric comparisons for quantitative variables was by Mann-Whitney testing. Linear Trend analyses were corrected for differences in age, sex, center and BMI, as were combined group comparisons using the General Linear Model (GLM).
| KLF6 | Linear Trend | AA vs AG+GG | AA+AG vs GG | |||
|---|---|---|---|---|---|---|
| AA | GA | GG | ||||
| Number | 12 | 155 | 1082 | |||
| Age (years) | 42.08±2.95 | 45.74±0.68 | 43.57±0.25 | na | ns | 0.006 |
| Sex (M:F)* | 6:6 | 71:84 | 481:599 | na | ns | ns |
| BMI | 23.72±1.29 | 25.97±0.33 | 25.53±0.12 | ns | ns | ns |
| Fat mass (kg/m2) | 15.43±2.37 | 22.12±0.75 | 20.94±0.27 | ns | 0.023 | ns |
| Glucose (mmol/l) | 4.79±0.20 | 5.01±0.05 | 5.08±0.02 | 0.003 | ns | 0.009 |
| FPI (pmol/l) | 20.21±3.47 | 31.36±1.51 | 32.86±0.68 | 0.022 | ns(0.050) | ns |
| HOMA-IR | 0.95±0.14 | 1.37±0.07 | 1.36±0.03 | ns | ns | ns |
| OGIS | 486.1±19.7 | 442.8±5.11 | 441.5±2.04 | 0.042 | ns | ns |
| M/I μmol min−1 (kg fat-free mass)−1 nmol−1 | 159.8±25.6 | 143.5±5.48 | 137.7±2.21 | ns | ns | ns |
| icl_OGTT (l/min/m2) | 2.20±0.29 | 1.65±0.65 | 1.62±0.0.56 | ns | 0.015 | ns |
| TG (mmol/l) | 79.00±7.92 | 110.05±6.09 | 107.40±2.23 | ns | ns | ns |
| WC (cm) | 82.41±4.76 | 87.70±1.01 | 86.58±0.38 | ns | ns | ns |
| KLF6 | Linear Trend | AA vs AG+GG | AA+AG vs GG | |||
|---|---|---|---|---|---|---|
| AA | GA | GG | ||||
| Number | 5 | 38 | 327 | |||
| Age (years) | 36.40±2.65 | 45.76±1.49 | 42.75±8.08 | na | ns | ns |
| Sex (M:F)* | 5:0 | 17:21 | 163:164 | na | ns | ns |
| BMI | 25.04±1.67 | 27.00±0.62 | 26.01±0.23 | na | ns | ns |
| Fat_mass (kg/m2) | 14.14±3.38 | 23.26±1.47 | 21.51±0.51 | na | ns | ns |
| Glucose (mmol/l) | 4.72±0.14 | 4.93±0.08 | 4.99±0.03 | 0.027 | ns | ns |
| FPI (pmol/l) | 18.54±3.33 | 26.50±2.52 | 30.98±1.23 | 0.005 | ns | 0.015 |
| EGP | 17.06±2.34 | 16.33±0.79 | 16.36±0.26 | ns | ns | ns |
| Hepatic Insulin Resistance | 343.46±101.9 | 422.30±44.3 | 496.29±19.1 | 0.022 | ns | 0.029 |
Key: BMI – Body Mass Index; HOMA-IR – homeostatic model assessment of insulin resistance; OGIS – ‘oral glucose insulin sensitivity’ index; M/I – whole-body insulin sensitivity measured by hyperinsulinaemic clamp; FPI – Fasting Plasma Insulin; TG – triglycerides; WC – waist circumference; GCR_b – Basal glucose clearance (production/concentration); icl_OGTT – endogenous ‘pre-hepatic’ clearance during OGTT. ns: not significant; na: not appropriate; KW-Kruskal Wallis test.