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. 2011 Nov 14;22(4):472–484. doi: 10.1111/j.1750-3639.2011.00542.x

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© 2011 The Authors; Brain Pathology © 2011 International Society of Neuropathology

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Amyloid (A) β Histelide. A. Section of middle frontal gyrus (MFG) from a late‐onset Alzheimer's disease (AD) (LOAD) case processed using Histelide technique. 5‐Bromo‐4‐chloro‐3‐indolyl phosphate (BCIP) deposits reveal plaque‐like structures in cortical gray matter as well as deposits in the subarachnoid space. B. Light microscopy showed amyloid angiopathy and numerous senile plaques in gray matter (×100). C. Higher magnification (×400) showed a dense amyloid deposit. D. Section of MFG from a control case; BCIP deposits are absent from cortical gray matter. E–F. Scatterplots for Aβ signal intensity for gray matter (SI_GM) in sections of MFG from control (●), late‐onset AD (■), autosomal dominant AD (▴), and Adult Changes in Thought (ACT) high‐cognitive performer (+) cases. Average (—) and standard error of the mean () are indicated. E. Aβ SI_GM was significantly greater in both LOAD and autosomal dominant AD cases (n = 12) compared with controls (n = 8, P < 0.001). F. Aβ SI_GM did not change significantly across Braak neurofibrillary tangle (NFT) stages among the ACT high performers (n = 79). However, Aβ SI_GM was significantly greater in AD cases (n = 12) compared with ACT cases with Braak NFT stage III or IV (P < 0.0001).

Inline graphic — Amyloid (A) β Histelide. A. Section of middle frontal gyrus (MFG) from a late‐onset Alzheimer's disease (AD) (LOAD) case processed using Histelide technique. 5‐Bromo‐4‐chloro‐3‐indolyl phosphate (BCIP) deposits reveal plaque‐like structures in cortical gray matter as well as deposits in the subarachnoid space. B. Light microscopy showed amyloid angiopathy and numerous senile plaques in gray matter (×100). C. Higher magnification (×400) showed a dense amyloid deposit. D. Section of MFG from a control case; BCIP deposits are absent from cortical gray matter. E–F. Scatterplots for Aβ signal intensity for gray matter (SI_GM) in sections of MFG from control (●), late‐onset AD (■), autosomal dominant AD (▴), and Adult Changes in Thought (ACT) high‐cognitive performer (+) cases. Average (—) and standard error of the mean () are indicated. E. Aβ SI_GM was significantly greater in both LOAD and autosomal dominant AD cases (n = 12) compared with controls (n = 8, P < 0.001). F. Aβ SI_GM did not change significantly across Braak neurofibrillary tangle (NFT) stages among the ACT high performers (n = 79). However, Aβ SI_GM was significantly greater in AD cases (n = 12) compared with ACT cases with Braak NFT stage III or IV (P < 0.0001).