Table 2.
Antitumor activity of PGE0001
| Tumora | Doseb (mg/kg) | Volume at start (mm3) | Number of days of growth | Growth rate (mm3/7 days1, 10 days2, or 15 days3) | T/C (%) | p valuec |
|---|---|---|---|---|---|---|
| HCA-7 colon | Controld | 132 | 7 | 104±421 | ||
| 200 | 7 | 63±191 | 60.8 | 0.039 | ||
| SW837 rectum | Controld | 144 | 15 | 118±353 | ||
| 200 | 15 | 47±423 | 39.9 | 0.043 | ||
| A549 lung | Controld | 144 | 15 | 453±2823 | ||
| 100 | 15 | 385±1993 | 85.1 | 0.707 | ||
| Controld,e | 10 | 850±3862 | ||||
| 100 | 10 | 322±1442 | 37.9 | 0.043 |
a
8 mice per group.
b
SID for 5 days.
c
Compared to vehicle control.
d
Control received vehicle only (0.1 ml).
e
Animals were given a second regimen of 5 days.