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. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: Eur J Neurosci. 2012 Feb 22;35(5):798–804. doi: 10.1111/j.1460-9568.2012.08013.x

Figure 4.

Figure 4

Time courses for the number of heroin infusions (A, B) or active lever presses (C, D) during A) fixed ratio-1 (FR-1) self-administration (n=14), B) progressive ratio (PR) self-administration (n=10), C) cue-induced reinstatement of extinguished heroin seeking (n=13), and D) heroin-induced reinstatement (n=9), following administration of SB-334867 (30 mg/kg) or vehicle. Significant overall effects are indicated by # (## p<0.01, ### p<0.001, n.s. = not significant), and significant post-hoc effects for individual time bins are indicated by * (*p<0.05, **p<0.01).