Table 1.

Details on three cohorts included in the collaboration.

Cohort	Citation	Recruitment	Inclusion	Exclusion
1	Cornish et al. 2008	United Kingdom Clinical Genetics Services and Fragile X Society	Age 18-50 English- speaking	IQ less than 85, stroke, dementia
2	Hunter et al. 2008	FXS conferences and support groups, word of mouth, sports events, health fairs, churches	Age 18-50 English- speaking	Active substance abuse/addiction, head trauma with loss of consciousness, meningitis, oxygen deprivation, Multiple Sclerosis, Amyotrophic Lateral Sclerosis, Parkinson’s disease, severe chronic fatigue syndrome, complicated migraines (temporary stroke-like effects) with progressive memory impairment, stroke or brain hemorrhage, brain surgery, seizure disorder, schizophrenia, active use of sedating medications
3	Grigsby et al. 2008, Brega et al. 2008	FXS study subjects at University of Colorado Denver and University of California Davis, FXS support groups, employees at CU Denver and Health Sciences Center	Over age 40 English- speaking	Significant speech/language deficits that make participation impossible, head trauma with loss of consciousness, epilepsy, demyelinating disease, family history of non- FXS genetic neurologic disorder, other neurologic disorders (e.g., stroke), complex medical comorbidities that may affect cognition, contraindications for MRI scanning (e.g., pacemaker, metal in body), schizophrenia, manic episodes, psychotic depression, alcoholism or significant drug use, medications affecting cognition

FXS=Fragile X Syndrome