Table 3.
FMR1 repeat length as a predictor of executive function measures: categorical (non-carrier vs. premutation carrier) and linear models (repeat length as a continuous variable). Models adjusted for age, education, and cohort.
Measure | Categorical Models | Linear Models | |||||
---|---|---|---|---|---|---|---|
Least Squares Means |
Repeat group partial R2 |
p-value | Repeat length standardized β estimates |
Repeat length partial R2 |
p-value | ||
NC | PM | ||||||
COWAT | 41.56 | 39.45 | 0.01 | 0.16 | −0.05 | <0.01 | 0.41 |
Stroop | 63.52 | 59.66 | 0.02 | 0.01 | −0.06 | 0.02 | 0.02 |
Backward digit span | 7.32 | 7.06 | <0.01 | 0.41 | −0.10 | 0.01 | 0.08 |
Letter-number sequencing | 11.68 | 11.34 | <0.01 | 0.31 | −0.06 | <0.01 | 0.27 |
Hayling | 1.33 | 2.43 | 0.12 | <0.01 | 0.36 | 0.12 | <0.01 |
WCST | 1.94 | 2.01 | <0.01 | 0.54 | 0.07 | 0.01 | 0.38 |
BDS | 20.57 | 18.84 | 0.07 | 0.03 | −0.16 | 0.03 | 0.18 |
NC=non-carrier; PM=premutation carrier; COWAT=Controlled Oral Word Association Test; WCST=Wisconsin Card Sorting Test; BDS=Behavioral Dyscontrol Scale