Table 2.
Changes in Lean Mass Upon Testosterone (T) Treatment Versus Placebo (Plc).
| Reference / Parameter | Preparation | Treatment Duration | Change T | Change Plc | Net Change | |||
|---|---|---|---|---|---|---|---|---|
| Total lean mass (kg) | ||||||||
| Marin 1993 [58] | Gel | 9 mo | 1.5 | 0.2 | 1.3 | |||
| Snyder 1999 [59] | Patch | 36 mo | 2.1 | -0.3 | 2.4 | |||
| Kenny 2001 [62] | Patch | 12 mo | 1.0 | 0.2 | 0.8 | |||
| Crawford 2003 [65] | Mixed esters | 12 mo | 1.8 | -0.5 | 2.3 | |||
| Ferrando 2003 [63] | TE | 6 mo | 4.2 | -2 | 6.2 | |||
| Steidle 2003 [66] | Gel | 3 mo | 1.7 | 0.6 | 1.1 | |||
| Steidle 2003 [66] | Patch | 3 mo | 0.9 | 0.6 | 0.3 | |||
| Wittert 2003 [61] | Oral TU | 12 mo | 1.0 | -1.0 | 2.0 | |||
| Casaburi 2004 [67] (no training) | TE | 10 wk | 2.3 | -0.21 | 2.51 | |||
| Casaburi 2004 [67] (training) | TE | 10 wk | 3.29 | 0.2 | 3.09 | |||
| Page 2005 [69] | TE | 36 mo | 3.7 | 0.0 | 3.7 | |||
| Kapoor 2006 [70] | Mixed esters | 3 mo | 1.23 | 0.67 | 0.56 | |||
| Svartberg 2008 [71] | Inj TU | 12 mo | 4.2 | 0.4 | 3.8 | |||
| Allan 2008 [57] | Patch | 12 mo | 0.8 | -0.3 | 1.1 | |||
| Emmelot-Vonk 2008 [10] | Oral TU | 6 mo | 1.1 | -0.3 | 1.4 | |||
| Srinivas-Shankar 2010 [68] | Gel | 6 mo | 1.1 | -0.2 | 1.3 | |||
| Aversa 2010 [85] | Inj TU | 24 mo | 4.8 | -0.1 | 4.9 | |||
| Aversa 2010 [87] | Inj TU | 12 mo | 4.2 | -0.6 | 4.8 | |||
Gel: testosterone gel
Patch : testosterone patch
TE: parenteral testoterone enanthate
Oral TU: oral testoterone undecanoate
Mixed esters: mixed parenteral testoterone esters
Inj TU: parenteral testoterone undecanoate