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. Author manuscript; available in PMC: 2012 Aug 1.

Published in final edited form as: Int J Radiat Biol. 2011 May 17;87(8):902–913. doi: 10.3109/09553002.2011.573439

Analysis using multiplex bioassay of the expression of (A) KC/CXCL1 and (B) MCP1 in the plasma of female C57BL/6J following LPS inhalation, administered at 12 months or 15 months, respectively, after 0, 1, 5, or 10 Gy TBI. A significantly more robust response was seen with respect to both chemokines relative to age-matched controls at all dose levels. The 10 Gy animals demonstrated a delayed peak in response (3 days versus 1 day after LPS challenge) for both cytokines and expression levels of KC remained elevated in the 10 Gy group until >7 days after challenge. Data are expressed as mean ± SEM and were analyzed using a two-factor analysis of variance and Bonferroni post tests (*p < 0.05 vs. same day 0 Gy controls; n=3/group).

Analysis using multiplex bioassay of the expression of (A) KC/CXCL1 and (B) MCP1 in the plasma of female C57BL/6J following LPS inhalation, administered at 12 months or 15 months, respectively, after 0, 1, 5, or 10 Gy TBI. A significantly more robust response was seen with respect to both chemokines relative to age-matched controls at all dose levels. The 10 Gy animals demonstrated a delayed peak in response (3 days versus 1 day after LPS challenge) for both cytokines and expression levels of KC remained elevated in the 10 Gy group until >7 days after challenge. Data are expressed as mean ± SEM and were analyzed using a two-factor analysis of variance and Bonferroni post tests (*p < 0.05 vs. same day 0 Gy controls; n=3/group).