Figure 1.

The implication of BLyS/BAFF expression status in the modulation of HIV-specific reponses. Control of HIV infection is reflected by the capacity to regulate BLyS/BAFF expression status at mucosal sites, where the main battle against HIV takes place, promoting efficient HIV-specific B- and T-cell responses, viewed to block systemic invasion by the virus. In contrast, breaching of systemic integrity and progression of HIV infection is reflected by the incapacity to control BLyS/BAFF levels at mucosal sites, leading to dysregulated B- and T-cell responses, impairing the generation of highly protective HIV-specific immunity.