Table 5. Mitochondrial carrier family: transporters directly coupled to amino acid metabolism.
| Systematic name | Gene name | Description (substrate specificity) | Transport in/out organelle | Reference |
|---|---|---|---|---|
| YPR021c | AGC1a | Aspartate-glutamate transport (Asp, Glu) | aspartate → out, in ← glutamate | Cavero et al. (2003) |
| YPL134c | ODC1 | Lysine and glutamate biosynthesis/lysine catabolism/nitrogen assimilation (α-ketoglutarate, α-ketoadipate) | α-ketoadipate → out, in ← α-ketoglutarate | Palmieri et al. (2001) |
| YOR222w | ODC2a | Lysine and glutamate biosynthesis/lysine catabolism/nitrogen assimilation (α-ketoglutarate, α-ketoadipate) | α-ketoadipate → out, in ← α-ketoglutarate | Palmieri et al. (2001) |
| YOR130c | ORT1a (ARG11) | Arginine biosynthesis (ornithine) | ornithine → out, in ← H+ | Crabeel et al. (1996); Palmieri et al. (1997); Soetens et al. (1998) |
| YBR291c | CTP1 | Lysine biosynthesis - Lys14 regulated; suggested role in peroxisome membrane (citrate, malate) | citrate → out, in ← malate | Breitling et al. (2002); Kaplan et al. (1995) |
| YKL120w | OAC1a | Leucine biosynthesis (oxalacetate, α-isopropyl malate) | α-isopropylmalate → out, in ← oxalacetate | Marobbio et al. (2008) |
| YBL089w | YMH2 | Arginine biosynthesis (citrate, α-ketoglutarate) | citrate → out, in → α-ketoglutarate | Castegna et al. (2010) |
| YHR002w | LEU5 | Leucine biosynthesis - CoA transport (cofactor A) | in | Prohl et al. (2001) |
| YPR058w | YMC1a | Lysine and glutamate biosynthesis (α-ketoglutarate) | n.d. | Trotter et al. (2005) |
| YBR104w | YMC2a | Lysine and glutamate biosynthesis (α-ketoglutarate) | n.d. | Trotter et al. (2005) |
| YNL003c | SAM5 (PET8) | Methionine biosynthesis (S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAHC)) | In ← SAM, SAHC → out | Marobbio et al. (2003) |
| ThPP = Thiamine pyrophosphate | ||||
| TMP = Thiamine monophosphate |
a
GAAC-regulated expression (Natarajan et al. 2001)