Figure 7.

Histopathological examination of the renal cortex using Masson's trichrome staining. Histopathological study of the renal cortex in native KK/HIJ and HFD-fed KK/HIJ mice after treatment with either 300 mg/kg/day Cordyceps sinensis (CS), 0.5 mg/kg/day rosiglitazone (RS), or the control group (saline) for 4 consecutive weeks. (a) In the native control group, the glomerulus (white arrow) remained relatively intact with positive collagen staining; weak collagen staining was present in tubules and the interstitium. (b) In KK/HIJ (HFD) mice treated with saline, obvious mesangial matrix accumulation with diffuse collagen fibril deposition in different compartments was observed. (c) In KK/HIJ mice treated with CS, the matrix accumulation and collage staining was less severe than that in controls. (d) In KK/HIJ mice treated with RS, obvious mesangial matrix accumulation and diffuse collagen staining within renal tissues were observed (Masson trichrome, 400x).