Table 3.

GM regional volume differences between DEL, UPD, and Healthy Weight Controls

Talairach Region	Peak Coordinate			k	Z Score	p Value
HWC > Del	x	y	z			FWE	uncor
L Middle Frontal Gyrus	−29	49	29	138	3.390	0.868	0.000
R Inferior Frontal Gyrus	42	48	2	4592	3.870	0.379	0.000
R Superior Frontal Gyrus	33	44	35	544	3.750	0.498	0.000
L Orbitofrontal Gyrus (BA 11)	−13	43	−22	401	3.460	0.811	0.000
* L Middle Frontal Gyrus (BA 8)	−26	22	51	2101	4.520	0.045	0.000
* Anterior Cingulate Gyrus (BA 24)	4	14	26	4981	5.120	0.003	0.000
L Putamen	−20	12	10	975	4.060	0.225	0.000
*L Precentral Gyrus (BA 6)/ L Middle Frontal Gyrus (BA 46)	−49	−7	8	119362	5.500	0.001	0.000
L Superior Frontal Gyrus	−22	−10	56	342	3.450	0.822	0.000
R Precentral Gyrus	30	−27	51	158	3.420	0.843	0.000
L Medial Frontal Gyrus (BA 6)	−5	−28	55	1024	3.890	0.365	0.000
*R Superior Temporal Gyrus (BA 22)/ Middle Temporal Gyrus	66	−35	7	85553	5.910	0.000	0.000
R Inferior Temporal Gyrus	63	−35	−27	177	3.380	0.877	0.000
L Inferior Parietal	−27	−57	40	517	3.610	0.662	0.000
HWC > UPD
* R Rectal Gyrus/ Superior Orbitofrontal Gyrus (BA 11)	2	41	−26	5680	4.47	0.055	0.000
R Inferior Orbital Gyrus	19	18	−26	180	3.56	0.711	0.000
R Caudate	22	17	9	105	3.24	0.952	0.001
L Caudate	−20	15	10	611	3.7	0.554	0.000
* L Inferior Frontal Gyrus (BA 47)/ Middle Frontal Gyrus (BA 46)	−48	14	−7	6926	4.65	0.027	0.000
L Inferior Frontal Gyrus	−54	11	25	627	3.6	0.675	0.000
L Anterior Cingulate (BA 33)	−6	10	27	238	3.53	0.746	0.000
L Hypothalamus	−3	−2	−11	557	3.4	0.863	0.000
L Middle Cingulate Gyrus (BA 24)	−2	−16	40	5476	4.14	0.172	0.000
* L Parahippocampal Gyrus/ Hippocampus	−22	−18	−22	12551	5.35	0.001	0.000
* R Hippocampus	25	−22	−18	5514	5.04	0.005	0.000
R Middle Temporal Gyrus (BA 22)	70	−34	2	216	3.36	0.888	0.000
UPD > Del
R Superior Frontal Gyrus	17	49	37	1194	4.030	0.244	0.000
L Superior Frontal Gyrus (BA 10)	−27	48	30	112	3.290	0.926	0.000
L Middle Frontal Gyrus	−48	44	12	233	3.280	0.935	0.001
L Middle Frontal Gyrus	−33	32	22	658	4.410	0.067	0.000
L Middle Frontal Gyrus (BA 8)	−27	23	50	928	3.840	0.414	0.000
R Inferior Frontal Gyrus	25	19	−15	687	3.720	0.533	0.000
Anterior Cingulate Gyrus	8	16	24	322	3.770	0.485	0.000
L Superior Frontal Gyrus (BA 10)	−3	14	67	111	3.290	0.927	0.000
R Middle Temporal Gyrus	36	8	−43	586	3.240	0.949	0.001
R Superior Frontal Gyrus	20	2	58	507	3.710	0.552	0.000
R Middle Temporal Gyrus	54	0	−19	2156	3.690	0.569	0.000
L Middle Temporal Gyrus	−51	−6	−16	677	3.480	0.795	0.000
*R Superior Temporal Gyrus (BA 41/22)	55	−20	7	14938	4.830	0.013	0.000
L Middle Temporal Gyrus	−49	−28	−16	218	4.300	0.100	0.000
L Superior Temporal Gyrus	−68	−40	20	10107	3.970	0.292	0.000
L Middle Temporal Gyrus	−54	−43	−7	297	3.610	0.660	0.000
R Superior Temporal Gyrus	51	−53	17	2238	4.220	0.134	0.000
* L Inferior Parietal	−35	−57	45	2783	5.180	0.003	0.000
R Middle Temporal Gyrus	38	−75	20	238	3.500	0.770	0.000
L Middle Temporal Gyrus	−32	−77	16	1911	4.400	0.070	0.000
Cerebellum	−16	−87	−27	8662	4.300	0.100	0.000
Cuneus (BA 19)	−16	−96	20	402	3.400	0.859	0.000
Del > UPD
No Clusters in Statistical Threshold

Listed Rostral to Caudal for each analysis; R= right, L= left, BA= Brodmann’s Area, uncor = uncorrected, k=cluster size, FWE= family wise error

^*Significant at p < .05 FWE corrected, regions in bold with no * are a trend at p<.08 FWE corrected. Clusters include all regions separated by a (/).