. Author manuscript; available in PMC: 2013 Mar 1.

Published in final edited form as: Am J Med Genet B Neuropsychiatr Genet. 2012 Mar;159B(2):243–253. doi: 10.1002/ajmg.b.32022

Table 4.

WM regional volume differences between Prader Willi Groups and Healthy Controls

Talairach Region	Peak Coordinate			k	Z Score	p Value

HWC > PWS	mm	mm	mm			FWE	uncorr
^* L Inferior Frontal White Matter	−48	30	11	63	4.75	0.010	0.000
^* L Precentral White Matter	−46	5	20	10	4.39	0.042	0.000
^* L Medial Temporal White Matter	−40	−7	−26	758	4.70	0.012	0.000
^* R Medial Temporal White Matter	41	−7	−26	84	4.47	0.031	0.000
^* Brainstem (Medulla)/Cerebellum	−11	−37	−48	152963	6.57	0.000	0.000

HWC > DEL

^* R Inferior Frontal White Matter	32	36	15	31	4.51	0.026	0.000
^* LInferior Frontal White Matter	−48	30	11	26	4.63	0.016	0.000
^* R Middle Temporal White Matter	47	−1	−31	283	4.58	0.020	0.000
^* Cerebellum/Brainstem/Thalamus	11	−43	−46	146327	6.46	0.000	0.000

HWC > UPD

^* R Anterior Cingulum	9	39	5	56	4.49	0.028	0.000
^* R Middle Frontal White Matter/R Cingulum	31	36	14	6336	5.42	0.000	0.000
^* L Inferior Frontal White Matter	−27	29	14	1751	4.76	0.010	0.000
^* L Inferior Frontal White Matter	−23	11	36	68	4.42	0.037	0.000
^* L Middle Temporal White Matter	−40	−8	−19	986	4.81	0.008	0.000
^* Thalamus/Brainstem/Cerebellum	−9	−10	15	71864	5.99	0.000	0.000

UPD > DEL

^* L Inferior Parietal White Matter	−38	−20	23	553	4.71	0.012	0.000
^* L Inferior Parietal White Matter	−34	−32	37	152	4.54	0.024	0.000
DEL> UPD
^* L Medial Orbital Frontal White Matter	−5	27	−10	75	4.57	0.021	0.000

Listed Rostral to Caudal for each analysis; R= right, L= left, uncorr = uncorrected, k=cluster size, FWE= family wise error

Significant at p < .05 FWE corrected, clusters include all regions separated by a (/).