Table 3.
Power for all tests in simulated data of scenario C weak common SNPs effect, effects of RVs are in the same direction
| OR | 1.3 | 1.6 | 1.9 | 2.2 | 2.5 | 2.8 | 3.1 |
|---|---|---|---|---|---|---|---|
| Rind | 0.237 | 0.394 | 0.472 | 0.6 | 0.715 | 0.785 | 0.843 |
| Rsum | 0.247 | 0.418 | 0.543 | 0.636 | 0.747 | 0.811 | 0.869 |
| Cbon | 0.163 | 0.157 | 0.144 | 0.164 | 0.174 | 0.191 | 0.193 |
| Clogit | 0.195 | 0.199 | 0.193 | 0.207 | 0.212 | 0.228 | 0.238 |
| Bind | 0.278 | 0.364 | 0.436 | 0.517 | 0.618 | 0.677 | 0.76 |
| Bsum | 0.298 | 0.384 | 0.461 | 0.562 | 0.668 | 0.735 | 0.795 |
| 0.236 | 0.43 | 0.565 | 0.702 | 0.781 | 0.888 | 0.91 | |
| 0.238 | 0.446 | 0.605 | 0.705 | 0.815 | 0.892 | 0.92 | |
| BwSum | 0.341 | 0.534 | 0.658 | 0.703 | 0.846 | 0.87 | 0.911 |
| BwOR | 0.253 | 0.312 | 0.344 | 0.475 | 0.456 | 0.582 | 0.648 |
| BKML | 0.167 | 0.186 | 0.186 | 0.19 | 0.204 | 0.199 | 0.2 |
| BSSU | 0.165 | 0.179 | 0.179 | 0.181 | 0.192 | 0.192 | 0.188 |
| BSSUw | 0.203 | 0.334 | 0.458 | 0.61 | 0.716 | 0.808 | 0.861 |
| BaSSU | 0.168 | 0.215 | 0.235 | 0.28 | 0.303 | 0.34 | 0.383 |
| BaSSUw | 0.181 | 0.346 | 0.399 | 0.546 | 0.64 | 0.755 | 0.819 |
| BaSSUOrd | 0.163 | 0.293 | 0.376 | 0.571 | 0.592 | 0.733 | 0.798 |
| BaSSUwOrd | 0.238 | 0.367 | 0.506 | 0.663 | 0.732 | 0.847 | 0.89 |
| BwSCd | 0.21 | 0.395 | 0.484 | 0.625 | 0.661 | 0.822 | 0.848 |
| BwSC | 0.344 | 0.538 | 0.631 | 0.778 | 0.85 | 0.935 | 0.954 |
There is customized LD structure among common variants and among rare variants.
The OR for underlying common SNP is 1.5. Genetic effect parameter OR for eight rare variants is listed in the table. If OR is 2, Odds Ratio = (2, 2, 2, 2, 3, 3, 3, 3) for eight casual rare variants. Notations of tests are defined similarly as those in Table 1.