Table 1.
Characteristic | Arm A:IMC-A12 (n = 23) |
Arm B: IMC-A12 +C (n = 21) |
Arm C: IMC-A12 + C and KRAS Wild Type (n = 20) |
All Treatments (N = 64) |
||||
---|---|---|---|---|---|---|---|---|
No. | % | No. | % | No. | % | No. | % | |
Sex | ||||||||
Female | 14 | 61 | 9 | 43 | 10 | 50 | 33 | 52 |
Male | 9 | 39 | 12 | 57 | 10 | 50 | 31 | 48 |
Age, years | ||||||||
Median | 59 | 63 | 62 | 61 | ||||
Range | 41-79 | 40-84 | 44-70 | 40-84 | ||||
ECOG performance status | ||||||||
0 | 3 | 13 | 5 | 24 | 10 | 50 | 18 | 28 |
1 | 20 | 87 | 16 | 76 | 10 | 50 | 46 | 72 |
Prior cetuximab | 21 | 91 | 21 | 100 | 20 | 100 | 61 | 95 |
Prior panitumumab* | 7 | 30 | 2 | 10 | 2 | 10 | 11 | 17 |
Prior FU, oxaliplatin, irinotecan | 23 | 100 | 21 | 100 | 20 | 100 | 64 | 100 |
Abbreviations: ECOG, Eastern Cooperative Oncology Group; FU, fluorouracil.
Only two patients on trial received panitumumab alone; all other patients also received cetuximab.