Table 4.

Incidence of EGFR Mutations by Cigarette Smoking History and Sex

Smoking History and Sex	Stage I-IIIA			Stage IIIB/IV			All Stages				P*
	No. With Mutations	Total No. of Tumors	%	No. With Mutations	Total No. of Tumors	%	No. With Mutations	Total No. of Tumors	%	95% CI
Never smokers
Female	101	176	57	116	222	52	217	398	55	49 to 59	.15
Male	30	52	57	55	130	42	85	182	47	39 to 54	χ2(df = 1) = 2.12
Total	131	228	57	171	322	53	302	580	52	48 to 56
Smokers
Female	60	514	12	69	403	17	129	917	14	12 to 16	.073
Male	27	343	8	45	302	15	72	645	11	9 to 14	χ2(df = 1) = 3.21
Total	87	857	10	114	705	16	201	1,562	13	11 to 15

^*P value was adjusted for stage.