Table 5. CpG DNA methylation in B19V DNA present in clinical samples.
Sample (Date) | Tissue | Clinical setting | Viral load | Met Index |
A.29 (07/09/2008) | Placenta | IUFD | 1.36E+03 | 0.111 |
GA.1 (06/07/2006) | Placenta | IUFD | 6.33E+06 | <0.001 |
BE.1 (12/06/2007) | Duodenum | Aplastic crisis | 6.97E+03 | 0.005 |
AP.1 (02/03/2005) | Ileum | IBD | ND | ND |
AP.2 (20/10/2005) | Ileum | IBD | ND | ND |
CM.1 (15/01/2009) | Myocardium | Myocarditis | 1.08E+03 | 0.136 |
CM.2 (18/02/2009) | Myocardium | Myocarditis | 3.17E+02 | 0.287 |
FV.1 (19/04/2010) | Myocardium | Myocarditis | 7.62E+03 | 0.511 |
ML.1 (21/02/2005) | Myocardium | Myocarditis | 2.43E+02 | 0.268 |
ML.2 (23/02/2005) | Myocardium | Myocarditis | 1.06E+03 | 0.296 |
ML.3 (09/03/2005) | Myocardium | Myocarditis | 6.09E+04 | 0.004 |
MN.1 (08/11/2005) | Myocardium | Myocarditis | 4.00E+03 | 0.423 |
MN.2 (23/11/2005) | Myocardium | Myocarditis | 2.33E+03 | 0.714 |
MN.3 (04/01/2007) | Myocardium | Myocarditis | 4.76E+03 | 0.605 |
Clinical samples, amount of viral DNA present in tissues (genome copies/100 ng cellular DNA) and analysis of methylation status of viral DNA as determined by MSP assay. IUFD: intrauterine fetal death; IBD: inflammatory bowel disease; ND: not determined.