Figure 5. Aging in mouse tail skin leads to an aberrantly weak inflammatory signature with decreased expression of Lyz1, Lyz2, Clec7a, Cd48, Tyrobp and Mpeg1.

Gene expression profiles associated with aging in mouse tail skin (first two columns in chart) were aligned with 28 other aging profiles from a panel of mouse tissues. All profiles were generated from datasets that included young and old mice, where the same Affymetrix Mouse Genome 430 2.0 array platform was used to generate each dataset (see Methods and Table S2 for further detail). The chart lists in rank-order the top 50 genes increased by aging across all profiles (based upon the total number of significant (age-increased) results among all profiles for a given gene). Colors within the chart denote the estimated 2-year fold change (old/young) for a given gene (row) and profile (column) (see color scale), while up and down-triangles denote significant aging effects (comparison-wise P<0.05). Several alternative versions of this chart with different gene-ranking schemes are shown in Figure S10.