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. 2012 Mar 7;7(3):e32922. doi: 10.1371/journal.pone.0032922

Figure 3. Bleeding pattern and uterine weight mirror changes such as tissue construction, breakdown, and repair.

Figure 3

Pseudopregnant BALB/c mice were treated according to Figure 2A and sacrificed before (day 4) or after decidualization (days 6, 7, 8, 9, 10, 12). A: Macroscopic analysis of uteri at indicated points in time. B: Microscopic analysis of H&E-stained uteri (S, stromal cells; E, epithelium; L, lumen; B, extravasated blood). C: Analysis of uterus weights (left axis; open square = individual data; bar = mean) and bleeding intensity determined by H&E scores according to Figure 1 (right axis; filled square and bar analogous to the preceding; N≥7). The two-tailed Spearman test indicates a significant correlation (p = 0.0167, Spearman r = 0.9429) between increased uterus weight and H&E score. Data were assigned to the respective time (day 4 to day 12) and to the dominant processes at that time (construction - blue, breakdown - red, repair - green).