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. 2011 Sep 21;21(3):482–489. doi: 10.1007/s00586-011-2020-2

Table 6.

Clinical trials using G-CSF injection

Author [ref.] Sample size Clinical scenario G-CSF dose (μg/kg/day) Route of administration Duration of G-CSF therapy (days) Peak WBC count (×103/μl)
Engelmann et al. [2] 23 AMI 10 s.c. 5 42.9 ± 25.7
Ince et al. [5] 15 AMI 10 s.c. 6 55 ± 8
Nefussy et al. [12] 19 ALS 5 s.c. 4 30.0 ± 7.2
Ripa et al. [15] 39 AMI 10 s.c. 6 51 ± 8
Shyu et al. [21] 7 CI 15 s.c. 5 42.9 ± 9.6
Takano et al. [22] 18 AMI 2.5 s.c. 5 29.4 ± 9
Valgimigli et al. [23] 10 AMI 5 s.c. 4 35 ± 11
Zohlnhofer et al. [27] 56 AMI 10 s.c. 5 48 ± 15
Our cases 5 Myelopathy 5 i.v. 5 26.7 ± 10.7
10 Myelopathy 10 i.v. 5 35.2 ± 7.2

CI cerebral infarction, AMI acute myocardial infarction, ALS amyotrophic lateral sclerosis, s.c. subcutaneous injection, i.v. intravenous injection