Table 1.

Clinical characteristics, psychiatric measures and hormone levels

	AN	HA	OB	HC
	N=15	N=12	N=17	N=20
Clinical Characteristics
Age (years)	26.1±1.6	27.3±1.8	29.9±2.0	27.4±1.6
Weight (kg)	51.4±1.3c,d	58.9±1.8c	85.8±4.0a,b,d	61.2±1.4a,c
Body mass index (kg/m2)	18.3±0.3b,c,d	20.9±0.4a,c	31.1±1.1a,b,d	22.3±0.3a,c
Ideal body weight (%)	79.6±0.8b,c,d	92.9±1.4a,c	131.0±4.3a,b,d	98.3±1.5a,c
Total body fat (g)	9.2±0.6c,d	14.2±0.7c	32.6±2.5a,b,d	16.8±0.8a,c
Body fat (%)	17.4±0.9b,c,d	23.6±0.8a,c	36.9±1.2a,b,d	26.7±1.1a,c
Age of menarche	13.1±0.4	12.9±0.3	12.3±0.4	12.8±0.3
Months of amenorrhea	66.2±17.2c,d	34.9±9.6c,d	0a,b	0a,b
Psychiatric Measures
HAM-D*	13.5±1.4b,c,d	6.9±1.2a,c,d	3.2±0.8a,b,d	1.1±0.4a,b,c
HAM-A**	11.4±1.5b,c,d	7.8±1.1a,c,d	3.5±0.8a,b,d	1.5±0.5a,b,c
Perceived Stress Scale***	19.9±1.4c,d	14.5±1.6d	9.7±1.2a	7.2±1.6a,b
Hormone Levels
Leptin (ng/ml)	2.8±0.5b,c,d	6.3±0.8a,c	23.8±2.8a,b,d	8.8±0.7a,c
Ghrelin (pg/ml)	1132±106c	1004 ±88c	528±48 a,b,d	1057±108c

Means±SEM. NS, non-significant. After correcting for multiple comparisons, p<0.05 vs.

^aAN,

^bHA,

^cOB,

^dHC.

Normal range:

^*HAM-D (Hamilton Rating Scale for Depression)<8,

^**HAM-A (Hamilton Rating Scale for Anxiety)<18,

^***Perceived Stress Scale <27.

AN, subjects with anorexia nervosa; HA, subjects with hypothalamic amenorrhea; OB, overweight or obese controls; HC, normal-weight healthy controls.