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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Nat Med. 2012 Feb 19;18(3):388–395. doi: 10.1038/nm.2686

Figure 3. Deletion of both Akt1 and Akt2 in livers results in hyperglycemia, glucose intolerance and insulin resistance.

Figure 3

Blood glucose in mice after overnight fast (a) and 4 hours feeding (b). (*** P < 0.001, n = 7, 8). (c) Oral glucose tolerance test. (d) Serum insulin before and fifteen minutes after glucose gavage. (e) Hyperinsulinemic–euglycemic clamp in the DLWT and DLKO mice. (f) Hyperinsulinemic–euglycemic clamp in the 2LWT and 2LKO mice. GIR: glucose infusion rate; HGP: hepatic glucose production; Rd: rate of glucose disposal. (* P < 0.05, *** P < 0.001, NS: not significant, n = 4, 5)