Table 2.
Associations between SNPs in the MMP1 promoter region and primary tumor thickness.
| SNP | # Patients (%)
|
P-valuea | P-valueb | ||
|---|---|---|---|---|---|
| Thin (≤1 mm) | Intermediate (1.01–4.00 mm) | Thick (>4 mm) | |||
| −1607 1G/2G (rs1799750) | |||||
| 1G | 81 (25.8) | 79 (29.5) | 10 (27.8) | 0.398 | 0.761 |
| 1G/2G | 160 (51.0) | 134 (50.0) | 14 (38.9) | ||
| 2G/2G | 73 (23.2) | 55 (20.5) | 12 (33.3) | ||
| 1G/2G + 2G/2G | 233 (74.2) | 189 (70.5) | 26 (72.2) | 0.611 | 0.482 |
| −839 G > A (rs473509) | |||||
| GG | 103 (32.5) | 94 (35.1) | 18 (50.0) | 0.127 | 0.062 |
| GA | 170 (53.6) | 126 (47.0) | 13 (36.1) | ||
| AA | 44 (13.9) | 48 (17.9) | 5 (1.9) | ||
| GA + AA | 214 (67.5) | 174 (64.9) | 18 (50.0) | 0.110 | 0.068 |
| −755 T > G (rs498186) | |||||
| TT | 106 (33.8) | 82 (30.8) | 12 (33.3) | 0.423 | 0.721 |
| TG | 146 (46.5) | 133 (50.0) | 13 (36.1) | ||
| GG | 62 (19.8) | 51 (19.2) | 11 (30.6) | ||
| TG + GG | 208 (66.3) | 184 (69.2) | 24 (66.7) | 0.749 | 0.532 |
| −519 A > G (rs1144393) | |||||
| AA | 122 (38.9) | 107 (40.1) | 19 (52.8) | 0.598 | 0.457 |
| AG | 154 (49.0) | 126 (47.2) | 14 (38.9) | ||
| GG | 38 (12.1) | 34 (12.7) | 3 (8.3) | ||
| AG + GG | 192 (61.1) | 160 (59.9) | 17 (47.2) | 0.272 | 0.211 |
| −422 A > T (rs475007) | |||||
| AA | 82 (26.0) | 76 (28.2) | 16 (43.2) | 0.157 | 0.078 |
| AT | 167 (52.9) | 132 (49.1) | 12 (32.4) | ||
| TT | 67 (21.2) | 61 (22.7) | 9 (24.3) | ||
| AT + TT | 234 (74.1) | 193 (71.8) | 21 (56.7) | 0.085 | 0.040 |
| −340 A > G (rs514921) | |||||
| AA | 165 (52.2) | 129 (48.1) | 20 (54.1) | 0.876 | 0.995 |
| AG | 121 (38.3) | 111 (41.4) | 14 (37.8) | ||
| GG | 30 (9.5) | 28 (10.5) | 3 (8.1) | ||
| AG + GG | 151 (47.8) | 139 (51.9) | 17 (45.9) | 0.561 | 0.957 |
| −320T > C (rs494379) | |||||
| TT | 185 (58.5) | 161 (60.3) | 22 (59.5) | 0.732 | 0.438 |
| TC | 108 (34.2) | 94 (35.2) | 13 (35.1) | ||
| CC | 23 (7.3) | 12 (4.5) | 2 (5.4) | ||
| TC + CC | 131 (41.5) | 106 (39.7) | 15 (40.5) | 0.912 | 0.879 |
SNP, single nucleotide polymorphism.
a
Two-sided chi-square test for genotype distribution.
b
Adjusted for age, sex, skin color, hair color, eye color, freckling in the sun as a child, sunburns, tanning ability, number of moles, dysplastic nevi, and first-degree relatives with any cancer.