Table 3.
Associations between SNPs in the MMP1 promoter region and ulceration status.
| SNP | # Patients (%)
|
P-valuea | OR (95% CI)
|
P-valueb | ||
|---|---|---|---|---|---|---|
| Ulceration absent | Ulceration present | Crude | Adjustedb | |||
| −1607 1G/2G (rs1799750) | ||||||
| 1G | 138 (37.6) | 20 (25.3) | 0.417 | 1.00 (Ref) | 1.00 (Ref) | 0.425 |
| 1G/2G | 256 (51.2) | 37 (46.8) | 1.00 (0.55–1.79) | 1.21 (0.66–2.21) | ||
| 2G/2G | 106 (21.2) | 22 (27.9) | 1.43 (0.74–2.76) | 1.58 (0.79–3.14) | ||
| 1G/2G + 2G/2G | 362 (72.4) | 59 (74.7) | 0.672 | 1.13 (0.65–1.94) | 1.32 (0.75–2.33) | 0.342 |
| −839 G > A (rs473509) | ||||||
| GG | 163 (32.6) | 35 (43.8) | 0.148 | 1.00 (Ref) | 1.00 (Ref) | 0.159 |
| GA | 256 (51.2) | 34 (42.5) | 0.62 (0.37–1.03) | 0.61 (0.36–1.04) | ||
| AA | 81 (16.2) | 11 (13.8) | 0.63 (0.31–1.31) | 0.62 (0.29–1.30) | ||
| GA + AA | 337 (67.4) | 45 (56.3) | 0.051 | 0.62 (0.39–1.01) | 0.61 (0.37–1.01) | 0.055 |
| −755 T > G (rs498186) | ||||||
| TT | 165 (33.2) | 18 (23.5) | 0.108 | 1.00 (Ref) | 1.00 (Ref) | 0.059 |
| TG | 234 (47.1) | 47 (58.0) | 1.84 (1.03–3.28) | 2.04 (1.12–3.73) | ||
| GG | 98 (19.7) | 15 (18.5) | 1.40 (0.68–2.91) | 1.40 (0.65–3.04) | ||
| TG + GG | 332 (66.8) | 62 (76.5) | 0.056 | 1.71 (0.98–2.99) | 1.85 (1.04–3.33) | 0.038 |
| −519 A > G (rs1144393) | ||||||
| AA | 192 (38.6) | 38 (47.5) | 0.268 | 1.00 (Ref) | 1.00 (Ref) | 0.361 |
| AG | 241 (48.5) | 35 (43.8) | 0.74 (0.45–1.21) | 0.76 (0.45–1.28) | ||
| GG | 64 (12.9) | 7 (8.8) | 0.55 (0.24–1.30) | 0.57 (0.24–1.37) | ||
| AG + GG | 305 (61.4) | 42 (52.6) | 0.134 | 0.70 (0.43–1.12) | 0.72 (0.44–1.18) | 0.195 |
| −422 A > T (rs475007) | ||||||
| AA | 128 (25.5) | 31 (39.5) | 0.023 | 1.00 (Ref) | 1.00 (Ref) | 0.022 |
| AT | 263 (52.5) | 30 (37.0) | 0.47 (0.27–0.81) | 0.45 (0.26–0.79) | ||
| TT | 110 (22.0) | 19 (23.5) | 0.71 (0.38–1.33) | 0.67 (0.35–1.28) | ||
| AT + TT | 373 (74.5) | 49 (60.5) | 0.014 | 0.54 (0.33–0.89) | 0.52 (0.31–0.86) | 0.012 |
| −340 A > G (rs514921) | ||||||
| AA | 261 (52.0) | 37 (46.3) | 0.322 | 1.00 (Ref) | 1.00 (Ref) | 0.278 |
| AG | 197 (39.2) | 32 (40.0) | 1.15 (0.69–1.91) | 1.20 (0.71–2.04) | ||
| GG | 44 (8.8) | 11 (13.8) | 1.76 (0.84–3.72) | 1.56 (0.70–3.48) | ||
| AG + GG | 241 (48.0) | 43 (53.8) | 0.341 | 1.26 (0.78–2.02) | 1.27 (0.77–2.09) | 0.344 |
| −320T > C (rs494379) | ||||||
| TT | 299 (59.8) | 42 (53.2) | 0.531 | 1.00 (Ref) | 1.00 (Ref) | 0.635 |
| TC | 172 (34.4) | 32 (40.5) | 1.33 (0.81–2.18) | 1.28 (0.76–2.16) | ||
| CC | 29 (5.8) | 5 (6.3) | 1.23 (0.45–3.35) | 1.23 (0.44–3.45) | ||
| TC + CC | 201 (40.2) | 37 (46.8) | 0.266 | 1.31 (0.81–2.11) | 1.27 (0.77–2.10) | 0.343 |
SNP, single nucleotide polymorphism; OR, odds ratio; CI, confidence interval.
a
Two-sided chi-square test for genotype distribution.
b
Adjusted for age, sex, skin color, hair color, eye color, freckling in the sun as a child, sunburns, tanning ability, number of moles, dysplastic nevi, and first-degree relatives with any cancer.