Table 4.
Associations between SNPs in the MMP1 promoter region and primary CM anatomic site.
| SNP | # Patients (%)
|
P-valuea | OR (95% CI)
|
P-valueb | ||
|---|---|---|---|---|---|---|
| Extremity | Axial | Crude | Adjustedb | |||
| −1607 1G/2G (rs1799750) | ||||||
| 1G | 88 (29.8) | 121 (27.2) | 0.335 | 1.00 (Ref) | 1.00 (Ref) | 0.177 |
| 1G/2G | 150 (50.9) | 218 (49.0) | 1.06 (0.75–1.49) | 1.20 (0.83–1.75) | ||
| 2G/2G | 57 (19.3) | 106 (23.8) | 1.35 (0.89–2.07) | 1.55 (0.98–2.45) | ||
| 1G/2G + 2G/2G | 207 (70.2) | 324 (72.8) | 0.435 | 1.14 (0.82–1.58) | 1.30 (0.91–1.84) | 0.146 |
| −839 G > A (rs473509) | ||||||
| GG | 93 (31.4) | 160 (35.8) | 0.465 | 1.00 (Ref) | 1.00 (Ref) | 0.412 |
| GA | 153 (51.7) | 215 (48.1) | 0.82 (0.59–1.14) | 0.80 (0.56–1.15) | ||
| AA | 50 (16.9) | 72 (16.1) | 0.84 (0.54–1.30) | 0.78 (0.48–1.25) | ||
| GA + AA | 203 (68.6) | 287 (64.2) | 0.218 | 0.82 (0.60–1.12) | 0.80 (0.57–1.12) | 0.185 |
| −755 T > G (rs498186) | ||||||
| TT | 114 (38.6) | 130 (29.4) | 0.031 | 1.00 (Ref) | 1.00 (Ref) | 0.011 |
| TG | 130 (44.1) | 226 (51.0) | 1.52 (1.10–2.12) | 1.71 (1.19–2.44) | ||
| GG | 51 (17.3) | 87 (19.6) | 1.50 (0.98–2.29) | 1.58 (1.00–2.52) | ||
| TG + GG | 181 (61.4) | 313 (70.6) | 0.009 | 1.52 (1.11–2.07) | 1.67 (1.20–2.34) | 0.003 |
| −519 A > G (rs1144393) | ||||||
| AA | 102 (34.8) | 187 (42.0) | 0.144 | 0.113 | ||
| AG | 150 (51.2) | 204 (45.8) | 0.74 (0.54–1.02) | 0.73 (0.52–1.04) | ||
| GG | 41 (14.0) | 54 (12.1) | 0.72 (0.45–1.15) | 0.64 (0.38–1.07) | ||
| AG + GG | 191 (65.2) | 258 (57.9) | 0.050 | 0.74 (0.54–1.00) | 0.71 (0.51–0.99) | 0.044 |
| −422 A > T (rs475007) | ||||||
| AA | 89 (29.9) | 125 (28.0) | 0.057 | 1.00 (Ref) | 1.00 (Ref) | 0.030 |
| AT | 133 (44.6) | 235 (52.7) | 1.26 (0.89–1.78) | 1.27 (0.87–1.85) | ||
| TT | 76 (25.5) | 86 (19.3) | 0.81 (0.53–1.22) | 0.74 (0.48–1.15) | ||
| AT + TT | 309 (70.1) | 321 (72.0) | 0.587 | 1.09 (0.79–1.51) | 1.07 (0.75–1.51) | 0.723 |
| −340 A > G (rs514921) | ||||||
| AA | 159 (53.5) | 224 (50.2) | 0.565 | 1.00 (Ref) | 1.00 (Ref) | 0.717 |
| AG | 113 (38.1) | 176 (39.5) | 1.11 (0.81–1.51) | 1.03 (0.74–1.44) | ||
| GG | 25 (8.4) | 46 (10.3) | 1.31 (0.77–2.21) | 1.27 (0.72–2.26) | ||
| AG + GG | 138 (46.5) | 222 (48.8) | 0.376 | 1.14 (0.85–1.53) | 1.07 (0.78–1.47) | 0.666 |
| −320T > C (rs494379) | ||||||
| TT | 173 (58.3) | 269 (60.5) | 0.702 | 1.00 (Ref) | 1.00 (Ref) | 0.880 |
| TC | 106 (35.7) | 146 (32.8) | 0.89 (0.65–1.21) | 0.92 (0.66–1.30) | ||
| CC | 18 (6.1) | 30 (6.7) | 1.07 (0.58–1.98) | 1.03 (0.54–1.99) | ||
| TC + CC | 124 (41.8) | 176 (39.5) | 0.550 | 0.92 (0.68–1.23) | 0.94 (0.68–1.30) | 0.703 |
SNP, single nucleotide polymorphism; OR, odds ratio; CI, confidence interval; Ref, reference.
a
Two-sided chi-square test for genotype distribution.
b
Adjusted for age, sex, skin color, hair color, eye color, freckling in the sun as a child, sunburns, tanning ability, number of moles, dysplastic nevi, and first-degree relatives with any cancer.