Table 2.
Classical HLA Class I/II genes and NPC
| Author /Yr |
Country | Sample Size (# Cases/# Ctrls) |
Genes Targeted |
Typing Method |
Main Findings | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| A*0207 | A*1101 | A*3303 | B*4601 | B*5801 | DRB1*0301 | DQB1*0201 | DQB1*0302 | DPB1*0401 | Other alleles | |||||
|
Tang32 (2010) |
China | 356/629 |
HLA-A HLA-B HLA-C |
PCR-SSOP | (+) | (−) | (+) | (0) | (+) | N/T | N/T | N/T | N/T |
HLA-A*0206 (+) HLA-B*5502 (−) Protection tended to be observed for individual alleles; risk for haplotypes. |
|
Yu33 (2009) |
Taiwan | 301/1010 (481 siblings, 212 spouses, 317 unrelated) |
HLA-A HLA-B |
SBT; PCR- SSOP |
(+) | (−) | (+) | (0) | (+) | N/T | N/T | N/T | N/T |
HLA-B*3802 (+) HLA-B*4601 protective in absence of HLA-A* 0207 |
|
Karanik iotis34 (2008) |
Greece | 101/300 |
HLA-DQA1 HLA-DQB1 |
PCR-SSP | N/T | N/T | N/T | N/T | N/T | N/T* | (0) | (0) | N/T |
DQA1*0103 (−) DQA1*0201 (−) |
|
Li35 (2007) |
Tunisia | 136/148 | HLA I | SBT | N/D | N/E** | N/E** | N/D | N/E** | N/T | N/T | N/T | N/T |
HLA-B14 (−) HLA- Cw08(−) HLA-B18 (+) HLA-B51 (+) HLA-B57 (+) HLA- B14/Cw08 (−) |
|
Butsch Kovacic 36 (2005) |
Taiwan | 213/200 | HLA-Cω | PCR-SSOP | N/E*** | N/E*** | N/E*** | N/E*** | N/E*** | N/E*** | N/E*** | N/E*** | N/E*** |
HLA-Cω*0302 (+) HLA-Cω*0401 (−) |
|
Hildesh eim37 (2002) |
Taiwan | 366/318 |
HLA-A, HLA-B, HLA-DRB1, HLA-DQB1, HLA-DPB1 |
PCR-SSOP | (+) | (−) | (0) | (+) | (+) | (+) | (+) | (−) | (0) |
HLA-A*0201 (0) HLA-A*3101 (−) HLA-B*13(−) HLA-B*39(−) |
PCR-SSOP (sequence-specific oligonucleotide probe), PCR-SSP (sequence specific primer), SBT (sequence based typing), N/T (Not tested), N/D (Not detected), N/E (Not evaluated).
*
HLA-DRB1 typing was performed but analysis was performed at low-resolution and therefore not considered for this review.
**
Not evaluated due to low frequency in population studied.
***
Not evaluated in this manuscript since previously reported in a separate publication.