Table 3.
Immune-related (non-classical HLA) genes in NPC
| Author/Yr | Country | Sample Size (#Cases/#Ctrls) |
Genes Targeted | Methods/Approach | Polymorphic Site(s) Evaluated (Significant Association Reported – Yes/No) |
|---|---|---|---|---|---|
| HLA Related Genes | |||||
| Hassen38 (2011) | Tunisia | 185/177 | HLA-E | PCR-ARMS/ Candidate | HLA-E*0103 (No) |
| Hirankarn39 (2004) | Thailand | 100/100 | HLA-E | PCR-SSOP/ Candidate | HLA-E*0103 (Yes) |
| Ghandri40 (2011) | Tunisia | 186/189 | HLA-G | PCR-RFLP/Candidate PCR-ARMS /Candidate |
1074A/T (No) 1597delC (No) 1537 C/A (No) |
| Jalbout41 (2003) | Tunisia | 140/274 | HSP70-2 | PCR-RFLP/Candidate | Pst I P1/P2 (Yes) |
| Douik42 (2009) | Tunisia | 130/180 | MICA | PCR-RFLP/Candidate | 454 A/G (Yes) |
| Tian43 (2006) | China | 218/196 | MICA | PCR size-sequencing/Candidate | MICA*A5.1 (Yes) MICA*A9 (Yes) |
| Hassen44 (2007) | Tunisia | 209/165 | TAP1 | PCR-ARMS /Candidate | Ile333Val (Yes) Asp637Gly (Yes) |
| Sousa45 (2011) | Portugal | 123/627 | TNF-α | PCR-SNP Genotyping/Candidate | −308G/A (Yes) |
| Jalbout41 (2003) | Tunisia | 140/274 | TNF-α | PCR-RFLP/Candidate | −308 G/A (No) |
| Cytokine and Chemokine Genes | |||||
| Yang46 (2011) | China | 248/296 | IL-1 | PCR-RFLP/Candidate | −889C/T (No) rs3783553 (Yes) |
| Zhu47 (2008) | China | 113/144 | IL-1B | PCR-RFLP/Candidate | −31T/C (No) −511C/T (Yes) |
| Wei48 (2010) | China | 180/200 | IL-2 | PCR-RFLP/Candidate | −330 T/G (Yes) 114 T/G (No) |
| Ben Nasr49 (2007) | Tunisia | 160/169 | IL-8 | AS-PCR/Candidate | −251T/A (Yes) |
| Wei50 (2007) | China | 280/290 | IL-8 | PCR-SSP/Candidate PCR-RFLP/Candidate |
678T/C (No) −251T/A(Yes) −353A/T (No) −738T/A (No) −845 T/C (No) |
| Farhat51 (2008) | Tunisia | 160/197 | IL-10 | AS-PCR/Candidate | −1082G/A (No) |
| Wei52 (2007) | China | 198/210 | IL-10 | PCR-RFLP/Candidate | −592A/C (No) −819 T/C (No) −1082 G/A (Yes) |
|
Ben Chaaben53 (2011) |
Tunisia | 247/284 | IL-12p40 | PCR-SSOP/Candidate | rs 3212227 (Yes) |
| Wei54 (2009) | China | 302/310 | IL-12B | PCR-RFLP/Candidate | rs 3212227 (Yes) |
| Gao55 (2009) | China | 206/373 | IL-16 | PCR-RFLP/Candidate | rs4072111 (No) rs4778889 (No) rs11556218 (Yes) |
| Nong56 (2009) | China | 250/270 | IL-18 | PCR-RFLP/Candidate | rs187238 (No) rs1946518 (Yes) |
| Farhat57 (2008) | Tunisia | 163/164 | IL-18 | PCR-RFLP/Candidate | rs187238 (No) rs1946518 (No) |
| Wei54 (2009) | China | 302/310 | IL- 27p28 | PCR-RFLP/Candidate | rs153109 (No) rs181206 (No) rs17855750 (No) |
| Farhat51 (2008) | Tunisia | 160/197 | IFN-γ | AS-PCR/Candidate | 874T/A (No) |
| Wei58 (2007) | China | 108/120 | TGF-β1 | PCR-RFLP/Candidate | −509C/T (Yes) 869T/C (Yes) |
| Innate Immune Response Genes | |||||
| Xu59 (2010) | China | 444/464 | DC-SIGN | SBT/All SNPs | −116G/T (No) −190A/G (No) rs735239 (No) rs735240 (Yes) rs2287886(Yes) rs4804803(No) |
| He60 (2007) | China | 434/512 | TLR3 | SBT/Candidate | 829A/C (Yes) 13766C/T (No) rs3775291 (No) rs5743312 (No) |
| Song61 (2006) | China | 486/529 | TLR 4 | PCR-ARMS/Candidate | 11350G/C (Yes) 11449C/T(No) |
| Zhou62 (2006) | China | 487/580 | TLR10 | PCR-ARMS/Tag-SNPs | rs10856837 (No) rs11096955 (No) rs11096956 (No) rs11466651 (No) rs11466652 (No) rs11466653 (No) rs11466655 (No) |
|
Butsch Kovacic36 (2005) |
Taiwan | 295/252 | KIR genes | PCR-SSP/Candidate | activating KIRs (No) inhibitory KIRs (No) |
| Other Immune-Related Genes | |||||
| Hirunsatit63 (2003) | Thailand | 175/317 | CR2IVS2 | PCR-RFLP/Candidate | −848C/T (No) |
| Xiao64 (2010) | China | 457/485 | CTLA-4 | PCR-RFLP/Candidate | rs231775 (Yes) |
| Cao65 (2010) | China | 582/613 | FAS | PCR-RFLP/Candidate | −1377G/A (Yes) |
| Zhu66 (2010) | China | 237/264 | FAS | PCR-RFLP/Candidate | −670A/G (No) |
|
Bel Hadj Jrad67 (2006) |
Tunisia | 170/224 | FAS | PCR-RFLP/Candidate | −670A/G (Yes) |
| Cao65 (2010) | China | 582/613 | FASL | PCR-RFLP/Candidate | −844T/C (Yes) |
| Zhou68 (2009) | China | 163/203 | NFKB1 | PCR-RFLP/Candidate | −94 ins/del ATTG (Yes) |
| Hirunsatit63 (2003) | Thailand | 175/317 | PIGRIVS3 | PCR-RFLP/Candidate | −156G/T(No) |
| Hirunsatit63 (2003) | Thailand | 175/317 | PIGR | PCR-ARMS /Candidate | 1093G/A (No) |
AS-PCR (allele-specific), PCR-ARMS (amplification refractory mutation system), CR2 (complement receptor 2), CTLA-4 (cytotoxic T-lymphocyte antigen 4), DC-SIGN (dendritic cell-specific intercellular adhesion molecule 3 grabbing non-integrin), FASL (FAS ligand), HSP (heat shock protein), IL (interleukin), ins/del (insertion/deletion), IFN-γ (interferon-gamma), KIR (killer cell immunoglobulin-like receptor), NFKB1 (Nuclear factor-κB), MICA (Major histocompatibility complex (MHC) class I chain–related A), PCR-SSOP (sequence-specific oligonucleotide probe), PCR-SSP (sequence specific primer), SBT (sequence based typing), PIGR (Polymeric immunoglobulin receptor), RFLP (Restriction fragment length polymorphism),TAP1 (transporter part of the antigen processing 1 gene), TGF-β1 (Transforming growth factor-β1), TLR (Toll-like receptor), TNF-α (Tumor Necrosis Factor Alpha)