Table 5.

Other Genes in NPC

Author/Yr	Country	Sample Size (#Cases/#Ctrls)	Genes Targeted	Methods/Approach	Polymorphism (Association Reported – Yes/No)
Cell Cycle Control
Ma⁸¹ (2011)	China	855/1036	BIRC5	TaqMan PCR/ Candidate	rs9904341 (Yes)
Sousa²² (2011)	Portugal	124/509	MDM2	PCR-RFLP/Candidate	rs2279744 (Yes)
Xiao²³ (2010)	China	522/722	MDM2	PCR-ARMS /Candidate	rs2279744 (Yes)
Zhou²⁴ (2007)	China	832/766	MDM2	SBT/Candidate	rs2279744 (Yes)
Xiao²³ (2010)	China	522/722	TP53	PCR-RFLP/Candidate	rs1042522 (Yes)
Sousa²⁵ (2006)	Portugal	107/285	TP53	PCR-SSP/Candidate	rs1042522 (Yes)
Tiwawech²⁶ (2003)	Thailand	102/148	TP53	PCR-RFLP/Candidate	rs1042522 (No)
Cell Adhesion/Migration
Ben Nasr H⁸² (2010)	Tunisia	162/140	E-cadherin	PCR-RFLP/Candidate	−160C/A (Yes)
Zhou²⁸ (2007)	China	593/480 239/286	MMP1	SBT/Candidate	rs1799750 (No)
Nasr⁸³ (2007)	Tunisia	174/171	MMP1	PCR-RFLP/Candidate	rs1799750 (Yes)
Shao²⁷ (2011)	China	370/390	MMP2	TaqMan PCR/ Candidate	rs243865 (Yes)
Zhou²⁸ (2007)	China	593/480 239/286	MMP2	SBT/Candidate	rs243865 (Yes) rs2285053 (Yes)
Zhou²⁸ (2007)	China	593/480 239/286	MMP3	SBT/Candidate	rs3025058 (No)
Zhou²⁸ (2007)	China	593/480 239/286	MMP7	SBT/Candidate	rs17880821 (No)
Zhou²⁸ (2007)	China	593/480 239/286	MMP9	SBT/Candidate	rs3918242 (No)
Nasr⁸³ (2007)	Tunisia	174/171	MMP9	PCR-RFLP/Candidate	rs3918242 (No)
Zhou²⁸ (2007)	China	593/480 239/286	MMP12	SBT/Candidate	rs2276109 (No)
Zhou²⁸ (2007)	China	593/480 239/286	MMP13	SBT/Candidate	rs17860523 (No)
Angiogenesis
Ben Nasr H⁸⁴ (2009)	Tunisia	180/169	COX-2	PCR-RFLP/Candidate	−765G/C (Yes)
Wang⁸⁵ (2010)	China	156/161	VEGF	PCR-RFLP/Candidate	rs699947 (Yes)^*
Nasr⁸⁶ (2008)	Tunisia	163/169	VEGF	PCR-RFLP/Candidate	rs699947 (Yes)^*
DNA Methylation
Chang⁸⁷ (2008)	Taiwan	259/250	DNMT3B	MALDI-TOF based mini- sequencing genotyping/ Candidate	−149C/T (No) −283T/C (No) −579G/T (No)
Cao⁸⁸ (2010)	China	529/577	MTHFR	PCR-RFLP/Candidate	677C/T (No) 1298A/C (Yes)
Others
Li⁸⁹ (2011)	China	175/279	ACE	PCR-RFLP/Candidate	insertion/deletion (I/D) (No)
Tsou⁹⁰ (2011)	Taiwan	176/176	Cav-1	PCR-RFLP/Candidate	rs1997623 (No) rs3757733 (No) rs3807987 (No) rs3807992 (No) rs7804372 (Yes) rs12672038 (No)
Feng⁹¹ (2008)	China	201/320	DLC-1	PCR-SSCP/Candidate	−29A/T (No)
Gao⁹² (2008)	China	173/206	EGF	PCR-RFLP/Candidate	rs4444903 (No)
Gao⁹² (2008)	China	173/206	EGFR	PCR-RFLP/Candidate	rs17337023 (No)
Zhang⁹³ (2011)	China	798/1019	TERT	Hot-PCR	MNS16A L/S (Yes)
Huang⁹⁴ (2011)	China	171/176	VDR	PCR-RFLP/Candidate	rs1544410 (No) rs10735810 (No)
Zheng⁹⁵ (2007)	China	531/480	N4BP2	sequencing/Candidate	loc123-e3l-snp2 (No) rs794001-SNP1 (No) rs1442855 (No) rs2252352 (No) rs2271395 (No) rs2347044 (No) rs17439810 (No) rs17511578 (No) rs17511668-SNP2 (No) rs17585937 (No)
He⁹⁶ (2005)	China	239/286	PLUNC	PCR-RFLP/Candidate direct sequencing	rs750064 (Yes) rs2752903 (Yes) rs1998149 (No)

ACE (angiotensin I-converting enzyme), BIRC5 (Baculoviral inhibitor of apoptosis repeat-containing 5 (also called as survivin)), Cav-1 (Caveolin-1), Cox-2 (Cyclooxygenase-2), DLC-1 (Deleted in liver cancer-1), DNMT3B (DNA methyltransferase 3B), EGF (epidermal growth factor), EGFR (epidermal growth factor receptor), MALDI-TOF (matrix-assisted laser desorption/ionization time-of-flight), MDM2 (Mouse double minute 2), MMP (matrix metalloproteinases), MTHFR (Methylenetetrahydrofolate reductase), N4BP2 (Nedd4 binding protein 2), PCR-ARMS (amplification refractory mutation system), PCR-SSCP (single-strand conformation polymorphism), PCR-SSP (sequence specific primer), PLUNC (palate, lung, and nasal epithelial clone), RFLP (Restriction fragment length polymorphism), SBT (sequence based typing), TERT (telomerase reverse transcriptase), VEGF (vascular endothelial growth factor), VDR (Vitamin D receptor).

While both studies that evaluated VEGF reported significant evidence for an association with NPC, the reported associations were in opposite directions.