Renal mRNA expression and renal interstitial fluid (RIF) levels of tumornecrosis factor alpha (TNFα) and interleukine-6 (IL-6) in kidneys of sham and streptozotocin-induced diabetic (DM) rats treated with vehicle (V), aliskiren (Alisk), hydrochlorothiazide (HCTZ), amlodipine (Amlo), and their combination. A and C, mRNA levels of TNFα and IL-6, respectively. B and D, RIF levels of TNFα and IL-6. Data are mean ± SEM. *P<0.05 vs. control; †P<0.05 vs. DM+V; ‡P<0.05 vs. DM+HCTZ; §P<0.05 vs. DM+Amlo.